化学品安全技术说明书


Material Safety Data Sheet
DIMETHYL FUMARATE, 99%
Section 1 - Chemical Product and Company Identification
MSDS Name: DIMETHYL FUMARATE, 99%
Catalog Numbers: 22218-0000, 22218-0250, 22218-1000
Synonyms:
Company Identification: Acros Organics BVBA
Janssen Pharmaceuticalaan 3a
2440 Geel, Belgium
Company Identification: (USA) Acros Organics
One Reagent Lane
Fair Lawn, NJ 07410
For information in the US, call: 800-ACROS-01
For information in Europe, call: +32 14 57 52 11
Emergency Number, Europe: +32 14 57 52 99
Emergency Number US: 201-796-7100
CHEMTREC Phone Number, US: 800-424-9300
CHEMTREC Phone Number, Europe: 703-527-3887
Section 2 - Composition, Information on Ingredients
CAS# Chemical Name: % EINECS#
624-49-7 DIMETHYL FUMARATE 99% 210-849-0
Hazard Symbols: XN

Risk Phrases: 21 36/37/38
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Harmful in contact with skin. Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye: Causes eye irritation.
Skin: Causes skin irritation. Harmful if absorbed through the skin.
Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation: Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Section 4 - First Aid Measures
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately.
Notes to Physician:
Section 5 - Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use agent most appropriate to extinguish fire.
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container.
Section 7 - Handling and Storage
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container.
Section 8 - Exposure Controls, Personal Protection
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 624-49-7:










Personal Protective Equipment
Eyes: Wear chemical splash goggles.
Skin: Wear chemical splash goggles.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators: Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Section 9 - Physical and Chemical Properties

Physical State: Crystals
Color: white
Odor: Not available
pH: Not available
Vapor Pressure: Not available
Viscosity: Not available
Boiling Point: 192 - 193 deg C @ 760 mmHg
Freezing/Melting Point: 102.00 - 105.00 deg C
Autoignition Temperature: Not available
Flash Point: Not available
Explosion Limits: Lower: Not available
Explosion Limits: Upper: Not available
Decomposition Temperature: Not available
Solubility in water: Not available
Specific Gravity/Density:
Molecular Formula: C6H8O4
Molecular Weight: 144.13
Section 10 - Stability and Reactivity
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials Incompatible materials, reducing agents, acids, bases.
Hazardous Decomposition Products Carbon monoxide, carbon dioxide.
Hazardous Polymerization Has not been reported.
Section 11 - Toxicological Information
RTECS#: CAS# 624-49-7: EM6125000

LD50/LC50: RTECS:
CAS# 624-49-7: Draize test, rabbit, eye: 250 ug/24H Severe;
Draize test, rabbit, skin: 20 mg/24H Moderate;
Oral, rat: LD50 = 2240 mg/kg;
Skin, rabbit: LD50 = 1250 mg/kg;
.

Carcinogenicity: DIMETHYL FUMARATE - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.

Other: See actual entry in RTECS for complete information. The toxicological properties have not been fully investigated.
Section 12 - Ecological Information
Not available Section 13 - Disposal Considerations
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - Transport Information

IATA IMO RID/ADR
Shipping Name: Not available Not available Not available
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 21 Harmful in contact with skin.
R 36/37/38 Irritating to eyes, respiratory system and skin.

Safety Phrases:
S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection.


WGK (Water Danger/Protection)
CAS# 624-49-7: Not available

Canada
CAS# 624-49-7 is listed on Canada's DSL List


US Federal
TSCA
CAS# 624-49-7 is listed on the TSCA Inventory.


Section 16 - Other Information
MSDS Creation Date: 7/16/1996
Revision #0 Date Original.



The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantibility or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential, or exemplary damages howsoever arising, even if the company has been advised of the possibility of such damages.


附件的两个不是这个，是另外一个公司的中英文。

富马酸二甲酯 MSDS 中文版
富马酸二甲酯 MSDS英文版

这里有一个食品方面的标准。供参考。
卫生部的指定检验方法2.

食品中富马酸二甲酯残留量的测定

1 范围

本方法规定了食品中富马酸二甲酯残留量的GC测定方法。

本方法适用于粮食、糕点、水果等食品中富马酸二甲酯残留量的测定。

本方法的检测限（LOD）为：25mg/kg。



2 规范性引用文件

下列文件中的条款通过本标准的引用而成为本标准的条款。凡是注日期的引用文件，其随后所有的修改单（不包括勘误的内容）或修订版均不适用于本标准，然而，鼓励根据本标准达成协议的各方研究是否可使用这些文件的最新版本。凡是不注日期的引用文件，其最新版本适用于本标准。

GB/T 6682 分析实验室用水规格和试验方法。



3 原理

样品中富马酸二甲酯（DMF）经提取净化后，用附氢火焰离子检测器的气相色谱仪进行分离测定，与标准系列比较定量。



4 试剂和材料

4.1除非另有说明，所有试剂均为分析纯，水：GB/T 6682规定的一级水。

4.2氯仿。

4.3无水硫酸钠。

4.4中性氧化铝（层析用60-80目）。

4.5标准溶液贮备液：0.1g富马酸二甲酯（含量99.9%），用少量氯仿溶解，转移到100ml容量瓶中，用氯仿稀释至刻度，该标准溶液含富马酸二甲酯1mg/ml。

4.6标准溶液使用液：分别吸取标准溶液5、10、15、20、25、30ml于100ml容量瓶中，用氯仿稀释至刻度，富马酸二甲酯浓度分别为50、100、150、200、250、300ug/ml。



5 仪器与设备

5.1气相色谱仪，附氢火焰离子检测器。

5.2匀浆机。

5.3粉碎机。



6 分析步骤

6.1样品制备。

6.1.1 粮食、糕点、及含水分少低脂类的固体食品。

称取5.0g或10.0g粉碎样品，置于250ml具塞三角烧瓶中，加30ml氯仿，振摇30min，用定性滤纸过滤，取10ml滤液，吹入氮气使浓缩至1ml,备用。

6.1.2 含脂肪较多的样品

称取粉碎样品10.0g，加中性氧化铝5－10g（视脂肪多少而定），以下按6.1.1"加30ml氯仿…"起，依法操作。

6.1.3 水果类

将水果去皮，切成碎片，加等量蒸馏水于匀浆机中匀浆后，称取20.0g匀浆液（相当于10g样品），加氯仿30ml，振摇30min，用定性滤纸过滤于125ml分液漏斗中，待分层后，用无水硫酸钠过滤，取滤液10ml，吹入氮气浓缩至1ml，待测。

6.2 测定

6.2.1色谱参考条件

a）色谱柱： 玻璃柱（内径3mm，长2m），内装涂以2％OV-101和6％OV-210混合固定液的60－80目Chromosorb W.AW DMCS(HP);

b）气流速度：氮气50ml/min；空气500ml/min;氢气35ml/min；。

c）温度：气化室及检测器200℃,柱温155℃。.

d) 进样量：1μL。

6.3.2 测定

注入1uL标准系列中各浓度标准使用液于气相色谱仪中，测得不同浓度富马酸二甲酯的峰高，以浓度为横坐标，相应的峰高值为纵坐标，绘制标准曲线。同时注射一定体积样品溶液，测得峰高与标准曲线比较定量。

6.2.3 阳性样品的确证

按照上述条件测定试样和标准工作溶液，如果试样中的质量色谱峰保留时间与标准工作溶液一致（变化范围在±2.5%之内）

条件许可可以通过GC—MS定性

6.2.4 空白实验

除不称取样品外，均按上述测定条件和步骤进行。

6.2.5 允许差

在重复性条件下获得的两次独立测定结果的绝对差值不得超过算术平均值的20%。



7. 结果计算

样品中富马酸二甲酯残留量按照下式计算：


X：样品中富马酸二甲酯残留量，mg/kg

A：测定样品液中富马酸二甲酯含量，ug/ml

V1：浓缩用样品提取液体积，ml

V2：样品氯仿提取液总体积，ml

V3：样品浓缩后的体积，ml

V4：标准溶液进样体积，ul

V5：样品溶液进样体积，ul

m：样品重量，g



8. 相关技术参数

方法最低检出限：25mg/kg。回收率在88.9％～94.2%范围内，其相对标准偏差在4.32％～9.07％的范围内。

thank for sharing

谢谢，总算找到我要的东西了

很好的东西，就是不知道精度能达到多少，现在要求小于 0.1ppm。难啊

wattsome 发表:标准，好像还没有正式发布。
SN 皮革、纺织品中富马酸二甲酯的测定方法-[url=https://insevent.instrument.com.cn/t/Mp]气相色谱质谱法[/url]

确实,我上周也收到供应商关于此种物质的调查啦.

附件是我们公司整理的相关产品的清单，希望对你能有所帮助

皮革、纺织品中富马酸二甲酯的[url=https://insevent.instrument.com.cn/t/Mp]气相色谱质谱测定方法的相关产品[/url]

谢谢7楼提供的方法

0.1ppm的限制，用GC-MS可以测试的准确不？

采用sim方法采集离子,可以达到0.1ppm,用113离子定量就可以了