索引：内质网蛋白29抗体说明书

中文名称 内质网蛋白29抗体 英文名称 ERp29 别    名 Chromosome 12 open reading frame 8; Endoplasmic reticulum lumenal protein ERp28; Endoplasmic reticulum protein 29; Endoplasmic reticulum protein 29 isoform 1; Endoplasmic reticulum protein ERp29; ERp28; ERp31; PDI-DB; C12orf8. 供 应 商 远慕生物 研究领域 肿瘤  细胞生物  免疫学  转录调节因子 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep, 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 内质网蛋白29抗体（石蜡切片需做抗原修复）  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 26kDa 细胞定位 细胞浆 性    状 Lyophilized or Liquid 浓    度 1mg/1ml 免 疫 原 KLH conjugated synthetic peptide derived from human ERp29 亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 内质网蛋白29抗体产品介绍 background: This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Function: Proper protein folding and post-translational modifications are essential for secretory protein export out of the endoplasmic reticulum. This task is accomplished by chaperone proteins such as protein disulfide isomerase (PDI), GRP94, and BiP. A recently characterized protein, designated ERp29, is closely related to these chaperone proteins and appears to be upregulated during ER stress conditions. ERp29 is a soluble 259-residue protein that is localized to the lumen of the endoplasmic reticulum in all mammalian cells. Research has shown that there are two primary domains within ERp29. The first is the C-terminal region that is a novel, all helical, fold that is most likely involved with ERp29 retention to the ER. The second is the N-terminal region that resembles that of PDI’s thioredoxin module. The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Subcellular Location: Endoplasmic reticulum Database links: Entrez Gene: 10961 Human Entrez Gene: 613357 Cow Entrez Gene: 67397 Mouse Entrez Gene: 117030 Rat Omim: 602287 Human SwissProt: P81623 Cow SwissProt: P30040 Human SwissProt: P57759 Mouse SwissProt: P52555 Rat Unigene: 75841 Human Unigene: 154570 Mouse Unigene: 32904 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.