推荐：E1A样分化抑制因子3抗体用途

中文名称 E1A样分化抑制因子3抗体 英文名称 EID3 别    名 E1A-like inhibitor of differentiation 3; EID 3; EID-1-like inhibitor of differentiation 3; EID-3; EID3; EID3_HUMAN; EP300 interacting inhibitor of differentiation 3; EP300-interacting inhibitor of differentiation 3; Non-SMC element 4, S. cerevisiae, homolog of, B; NSE4B; NSMCE4B. 供 应 商 远慕生物 研究领域 细胞生物  信号转导  细胞周期蛋白  转录调节因子  表观遗传学 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep, 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 E1A样分化抑制因子3抗体（石蜡切片需做抗原修复）  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 38kDa 细胞定位 细胞核 细胞浆 性    状 Lyophilized or Liquid 浓    度 1mg/1ml 免 疫 原 KLH conjugated synthetic peptide derived from human EID3 亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. E1A样分化抑制因子3抗体产品介绍 background: Act as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.Tissue specificity: Highly expressed in testis. Function: Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.  Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.  Subunit: Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NDNL2 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2 (By similarity). Interacts with the C-terminal region of CREBBP.  Subcellular Location: Nucleus. Cytoplasm. Chromosome, telomere (Probable). Note=May shuttle between nucleus and cytoplasm.  Tissue Specificity: Highly expressed in testis. Similarity: Belongs to the NSE4 family. Gene ID: 493861 Database links: Entrez Gene: 493861 Human Entrez Gene: 66341 Mouse Entrez Gene: 691688 Rat Omim: 612986 Human SwissProt: Q8N140 Human SwissProt: Q3V124 Mouse SwissProt: Q4V8G2 Rat Unigene: 659857 Human Unigene: 443284 Mouse Unigene: 206488 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.