行情：骨骼肌烯醇化酶抗体说明书

中文名称 骨骼肌烯醇化酶抗体 英文名称 ENO3 别    名 2 phospho D glycerate hydrol yase; 2 phospho D glycerate hydrolyase; Beta enolase; ENO3; Enolase 3 (beta muscle); Enolase 3; Enolase3; GSD13; MSE; Muscle specific enolase; Skeletal muscle enolase; ENOB_HUMAN. 供 应 商 远慕生物 研究领域 肿瘤  细胞生物  免疫学 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 骨骼肌烯醇化酶抗体（石蜡切片需做抗原修复）  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 47kDa 性    状 Lyophilized or Liquid 浓    度 1mg/1ml 免 疫 原 KLH conjugated synthetic peptide derived from human ENO3 亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 骨骼肌烯醇化酶抗体产品介绍 background: ENO3 is also known as beta enolase, one of the three enolase isoenzymes found in mammals. A switch from alpha enolase to beta enolase occurs in muscle tissue during development and ENO3, a homodimer, is found in skeletal muscle cells in the adult and appears to have a function in striated muscle development and regeneration. Mutations can result in decreased stability of the enzyme and be associated with a glycogen storage myopathy. This results in exercise-induced myalgias, generalized muscle weakness and fatigability. Function: Appears to have a function in striated muscle development and regeneration. Subunit: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific. Interacts with PNKD. Subcellular Location: Cytoplasm. Note=Localized to the Z line. Some colocalization with CKM at M-band (By similarity). Tissue Specificity: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. DISEASE: Glycogen storage disease 13 (GSD13) [MIM:612932]: A metabolic disorder that results in exercise-induced myalgias, generalized muscle weakness and fatigability. It is characterized by increased serum creatine kinase and decreased enolase 3 activity. Dramatically reduced protein levels with focal sarcoplasmic accumulation of glycogen-beta particles are detected on ultrastructural analysis. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the enolase family. Database links: UniProtKB/Swiss-Prot: P13929.5 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.