索引：嗜酸性粒细胞过氧化物酶抗体用途

中文名称 嗜酸性粒细胞过氧化物酶抗体 英文名称 EPX 别    名 Eosinophil peroxidase; Eosinophil peroxidase heavy chain; EPER; EPO; EPP; EPX PEN; PERE; PERE_HUMAN. 供 应 商 远慕生物 研究领域 肿瘤  免疫学 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 嗜酸性粒细胞过氧化物酶抗体（石蜡切片需做抗原修复）  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 79kDa 性    状 Lyophilized or Liquid 浓    度 1mg/1ml 免 疫 原 KLH conjugated synthetic peptide derived from human Eosinophil peroxidase heavy chain 亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 嗜酸性粒细胞过氧化物酶抗体产品介绍 background: EPX, eosinophil peroxidase, is an antimycobacterial protein that localizes to cytoplasmic granules of eosinophils and recruits bromide to generate a halogenating oxidant. EPX dependent generation of hypobromous acid causes damage to tissue during inflammatory conditions that include asthma, allergies,cancer and parasitic/helminthic infections. EPX is a major enzyme present in eosinophils and upon degranulation, becomes released into the airways of asthmatics. As a result of its cationic nature and its ability to catalyze the formation of highly toxic oxidants, EPX can induce lung injury in a JNK dependent manner.  Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. Subunit: Tetramer of two light chains and two heavy chains. Subcellular Location: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils. DISEASE: Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining. Similarity: Belongs to the peroxidase family. XPO subfamily. Database links: UniProtKB/Swiss-Prot: P11678.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.