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in this application example, it is shown how specially tailored nanostructured plasmonic substratescan provide a means for location specific sensing. By fabrication of nanowells, surfaces with 'negativecurvature' are introduced, mimicking e.g. the inside of a vesicular membrane. Location specificnanoplamonic sensing allows distinguishing between the response from biomolecular interactionsinside the wells from the in-between planar regions.
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