Analysis and Purification Methods in Combinatorial Chemistry（分离与纯化）

CHAPTER 1 QUANTITATIVE ANALYSIS IN ORGANIC SYNTHESIS WITH NMR SPECTROSCOPY 3 Laura H. Lucas and Cynthia K. Larive CHAPTER 2 19F GEL-PHASE NMR SPECTROSCOPY FOR REACTION MONITORING AND QUANTIFICATION OF RESIN LOADING 37 Joseph M. Salvino CHAPTER 3 THE APPLICATION OF SINGLE-BEAD FTIR AND COLOR TEST FOR REACTION MONITORING AND BUILDING BLOCK VALIDATION IN COMBINATORIAL LIBRARY SYNTHESIS 53 Jason J. Cournoyer, Clinton A. Krueger, Janice V.Wade, and Bing Yan CHAPTER 4 HR-MAS NMR ANALYSIS OF COMPOUNDS ATTACHED TO POLYMER SUPPORTS 71 Meritxell Guinó and Yolanda R. de Miguel v CHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME MONITORING AND OPTIMIZATION OF COMBINATORIAL MATERIALS AND PROCESS CONDITIONS 87 Radislav A. Potyrailo, Ronald J. Wroczynski, John P. Lemmon,William P. Flanagan, and Oltea P. Siclovan CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE POLYMERIC SUPPORT 125 Christine Enjalbal, Frederic Lamaty, Jean Martinez, and Jean-Louis Aubagnac PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL 137 CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES FOR COMBINATORIAL CHEMICAL LIBRARY ANALYSIS 139 Ting Hou and Daniel Raftery CHAPTER 8 MICELLAR ELECTROKINETIC CHROMATOGRAPHY AS A TOOL FOR COMBINATORIAL CHEMISTRY ANALYSIS: THEORY AND APPLICATIONS 175 Peter J. Simms CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL ENCODED COMBINATORIAL LIBRARIES 209 Jing Jim Zhang and William L. Fitch PART III HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY 253 CHAPTER 10 STRATEGIES AND METHODS FOR PURIFYING ORGANIC COMPOUNDS AND COMBINATORIAL LIBRARIES 255 Jiang Zhao, Lu Zhang, and Bing Yan vi contents CHAPTER 11 HIGH-THROUGHPUT PURIFICATION: TRIAGE AND OPTIMIZATION 281 Jill Hochlowski CHAPTER 12 PARALLEL HPLC IN HIGHTHROUGHPUT ANALYSIS AND PURIFICATION 307 Ralf God and Holger Gumm PART IV ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY 321 CHAPTER 13 ORGANIC COMPOUND STABILITY IN LARGE, DIVERSE PHARMACEUTICAL SCREENING COLLECTION 323 Kenneth L. Morand and Xueheng Cheng CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN BIOMOLECULAR RECOGNITION 351 Ming-Chung Tseng, I-Nan Chang, and Yen-Ho Chu CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICAL PROFILING: POTENTIAL AND LIMITATIONS 369 Bernard Faller CHAPTER 16 SOLUBILITY IN THE DESIGN OF COMBINATORIAL LIBRARIES 407 Christopher Lipinski CHAPTER 17 HIGH-THROUGHPUT DETERMINATION Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt Jr., and James J. Bao INDEX 457