专家著述(2002)：用液流操纵单个DNA分子形成纳米悬链线图形

【中文摘要】 首先用液流拉伸单分子DNA ,使其吸附在修饰过的云母基片上 .然后让二次液流沿着垂直于已拉伸的DNA的方向流过云母片 ,用原子力显微镜 (AFM)观测 ,可见DNA单分子片段在基片上形成了一些纳米尺度的悬链线 .提出一种“S 悬桥”模型能定量地解释这一现象 .该研究工作揭示 ,在DNA的单分子操作中 ,经典的弹性力学理论足以描述和控制DNA分子二维图形的形成 【英文摘要】 Individual DNA molecules were firstly stretched by a liquid flow and adsorbed on a modified mica surface. A second liquid flow was then guided across the surface along a direction perpendicular to the aligned DNA strands. Some catenary like nano patterns of DNA molecules were formed, which were revealed by an atomic force microscope. A physical mechanism called “s suspension bridge" model has been presented, by which the features of the catenary like patterns of DNA molecules could be quite well underst...