专家著述(2005)：基于原子力显微镜技术的单个生物大分子压弹性研究

【中文摘要】 单个生物大分子力学性质已经成为一个新兴的研究领域,近几年来由于单分子技术的不断发展,这个领域取得了很多突破性的进展。本文介绍了基于原子力显微镜技术的几种单分子压弹性测量技术及这些技术的具体应用,同时也简要阐述了这些技术的局限性。另外对这个领域的发展也进行了初步地探讨。 【英文摘要】 The study of the mechanical properties of single biomacromolecules has emerged as a new field in which great advances have been made recently due to the developments in single molecular experimental techniques.Here we introduced some measurement techniques based on the atomic force microscopy for compression elasticity of single molecules,and demonstrated the concrete applications and the limitations of these techniques.In addition,the advances in this exciting field were also prospected.