利用两种先进的生物物理技术表征弱结合反应:氢氘交换质谱(HDX-MS)以及差式扫描量热(DSC)

A combination of HDX –MS and DSC is capable of revealing important structural details for biopharmaceuticals that cannot be obtained using other techniques HDX can map changes in binding regions and define structure of weak binding sites DSC characterization ensures highest quality structural data for differentiating weak binding molecular variants HDX-MS & DSC provide powerful, flexible analysis tools for DD, R&D and QC