用高分辨TGA表征药品中的结构水和自由水

The amount of moisture in pharmaceutical formulations is an important quality control parameter because it can affect their long-term stability and ultimate effectiveness as well as short-term processability. Techniques such as Karl Fischer titration, moisture evolution analysis (1,2), and thermogravimetric analysis (TGA) have been used for determining pharmaceutical moisture levels. However, these techniques often have trouble differentiating between “free” surface water (the source of problems) and bound water present in the chemical formulation.