激活素受体1B抗体

激活素受体1B抗体 Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor beta (TGF beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand binding extracellular domain with a cysteine rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Also known as: Activin A receptor type 1B; Activin A receptor type II like kinase 4; Activin A type 1B receptor; Activin A type IB receptor; Activin receptor like kinase 4; Activin receptor type 1B; ACTR IB; ACTRIB; ACVR 1B; ACVR1B; ACVRLK 4; ACVRLK4; ALK 4; ALK4; Serine(threonine) protein kinase receptor R2; SKR 2; SKR2.