锤子
消耗积分 : 免积分
We report herein a method that allows for the formation of a CeN bond between the Ce3 carbon of alactams and the nitrogen atom of indoles. A general procedure for the coupling of indoles and a-lactams in only 25 min with high yield is reported. The scope of the reactionwas extended by the development of a method for the in situ generation of less stable phenyl-substituted a-lactams. The developed method provides an atom-economical method for the formation of substituted a-amino amides that are found in a variety of biologically-active compounds.
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