AN#129生物分子间相互作用和靶向药物输送的流体力学效应的研究

Blood stream hydrodynamics is known to be an important pharmacokinetic factor that varies in different vessels and organs throughout the body. Liposomes are used in drug delivery systems to carry drug molecules to the effective site with some products already on the market. Liposomes are also widely studied as drug delivery systems for new drug targeting applica?tions. Multi Parametric Surface Plasmon Resonance (MP-SPR) is an in vitro label free method capable of providing information about interfacial adsorption events and molecular interaction kinetics. The SPR Navi 200 instrument′s open design allows easy custom?ization and control of the hydrodynamic conditions inside the measurement chamber. The Quartz Crystal Microbalance technique (QCM) senses the amount of water dynamically coupled to biomolecules, which is sometimes a useful additional information, but which can also be a complicating factor in assays. The difference in the hydrodynamic flow conditions for SPR and QCM