液质连用分析青霉素、头孢霉素用奥特IBD柱方法

侯先生 13691497252 Excellent LC/MS Separation of Penicillins and Cephalosporins Using Ultra IBD Columns Antibiotics are the most widely used medications in the world. Whether by prescription, addition to animal feed stocks, or use of cleaning agents, everyone in the civilized world is either directly or indirectly exposed to antibiotics in daily life. The overuse of antibiotics, however, has allowed resistant bacteria to thrive. The death of 12,500 people in Guatemala from an episode of Shingella fever can be traced to a simple mutation of the bacterial strain. Research indicated that the bacterium incorporated a single plasmid into its RNA sequence and resultantly became resistant to four different antibiotics. This illustrates the danger of resistance caused by adaptation. To combat resistant bacteria, new antibiotic derivatives must be created to overcome the bacteria’s new defense mechanisms. Typically, HPLC columns can be used to analyze penicillins and their structurally related cephalosporins. However, the similarity of many derivatives may require additional interactions to effectively separate related compounds. Restek’s Ultra IBD column is better able to resolve these compounds using polar and hydrophobic interactions.