Attaching Antibodies to AFM Probes with the Sulfhydryl Reactive PEG Tether, NHS-PEG18-PDP

AFM probes can be transformed into sensitive, chemically selective biosensors by attaching ligand molecules to the tips of the probes. Single-molecule molecular recognition force microscopy (MRFM) is an AFM-based technique that relies heavily on probes that have been modified with ligand molecules [Riener et al. 2003,Hinterdorfer 2004].