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Novel pyropheophorbide-a-conjugated multifunctional magnetofluorescence nanoparticles Fe3O4@SiO2@APTES@Glutaryl-PPa (MFNPs) with a mean diameter of 50 nm were strategically designed and prepared for photodynamic therapy (PDT) and medical fluorescence imaging. Chlorin photosensitizer pyropheophorbide-a (PPa) was covalently anchored on the surface of core–shell Fe3O4@SiO2@APTES nanoparticles that were prepared via a sol–gel process with a bridging glutaryl group.
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