死亡受体3，4，5诱导的细胞凋亡通路图

死亡受体3，4，5(DR3,4,5)是肿瘤坏死因子受体(tnfR)超家族中的新型死亡受体。DR3，4,5与TN-FR1一样,既能诱导凋亡也能活化核因子。κB(NF-κB),对淋巴细胞的发育和功能具有重要意义。 Apoptosis is specifically induced via signaling through a family of receptors known collectively as 'death receptors' including Fas, TNFR, DR3, -4 and -5. Death receptor ligands characteristically initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades. Apo3L recruits initiator caspase 8 via the adapter protein FADD. Caspase 8 then oligomerizes and is activated via autocatalysis. Activated caspase 8 stimulates apoptosis via two parallel cascades: it directly cleaves and activates caspase-3, and it cleaves Bid (a Bcl-2 family protein). Truncated Bid (tBid) translocates to mitochondria, inducing