ACID-BASE PARTITION CLEANUP

2.1 The solvent extract from a prior solvent extraction method is shaken with water that is strongly basic. The acid analytes partition into the aqueous layer, whereas, the basic and neutral compounds stay in the organic solvent. The base/neutral fraction is concentrated and is then ready for further cleanup, if necessary, or analysis. The aqueous layer is acidified and extracted with an organic solvent. This extract is concentrated (if necessary) and is then ready for analysis of the acid analytes.