使用LC-MS MS检测人血浆中的17种抗癫痫药及其代谢产物

2018/03/13   下载量： 11 次

方案摘要

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应用领域 医疗/卫生
检测样本 全血/血清/血浆
检测项目 生化检验>药物及其代谢物
参考标准 TSQ

The quantification of a panel of antiepileptic drugs in human plasma has been implemented and analytically validated on a TSQ Quantum Access MAX mass spectrometer using the MassTox TDM Series A kit for antiepileptics from Chromsystems. The TSQ Quantum Access MAX mass spectrometer proved to have the proper sensitivity, accuracy, and precision for the application of this analytical method to clinical research.

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方案详情

Antiepileptic drugs, antiepileptics, AEDs, anticonvulsants, antiseizure drugs,
liquid chromatography, triple quadrupole mass spectrometry, 
TSQ Quantum Access MAX

Implement an LC-MS/MS method for the quantification of 17 antiepileptics
and their metabolites in human plasma.

Liquid chromatography coupled to tandem mass
spectrometry (LC-MS/MS) is a valuable tool that can help
clinical researchers to monitor that antiepileptic drugs
remain within the desired range. Here, an LC-MS/MS
method on the Thermo Scientific™ TSQ Quantum Access
MAX™ triple quadrupole mass spectrometer was used
with the MassTox® TDM Series A kit for antiepileptics
from Chromsystems™ to quantify a panel of 17
antiepileptics and their metabolites in human plasma. 
The MassTox TDM Series A kit includes levetiracetam,
theophylline, felbamate, lacosamide, rufinamide,
carbamazepine, oxcarbazepine, carbamazepine diol,
carbamazepine-10,11-epoxide,
10-hydroxycarbamazepine, phenylethylmalonamide
(PEMA), primidone, phenytoin, stiripentol, zonisamide,
phenobarbital, valproic acid, and 12 internal standards.

The quantification of a panel of antiepileptic drugs in
human plasma has been implemented and analytically
validated on a TSQ Quantum Access MAX mass
spectrometer using the MassTox TDM Series A kit for
antiepileptics from Chromsystems. The TSQ Quantum
Access MAX mass spectrometer proved to have the
proper sensitivity, accuracy, and precision for the
application of this analytical method to clinical research.

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赛默飞色谱与质谱
钻石会员 丨 第23年
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