使用TSQ Altis三重四极杆质谱仪对血浆中候选药物混合物进行灵敏、稳健的定量分析

2018/03/13   下载量： 8 次

方案摘要

方案下载
应用领域 医疗/卫生
检测样本 全血/血清/血浆
检测项目 生化检验>药物及其代谢物
参考标准 TSQ Altis

The method referenced in this application note shows excellent linearity and reproducibility over the dynamic range of the assay. This method demonstrates that the TSQ Altis MS provides the sensitivity and reproducibility required in the analysis of pharmaceutical compounds.

方案下载
配置单
方案详情

To develop a sensitive, robust, reproducible LC-MS/MS assay for
determination and quantitation of a mixture of compounds of pharmaceutical
interest in human plasma and plasma from preclinical animal species.

Small molecules represent a significant proportion of drug discovery
and development in the search for new chemical entities, in addition to
the extensive work involved in the regulatory filings of generics. Targeted
quantitation assays are a critical part of an optimal workflow, which is
required to successfully develop a small molecule drug. These targeted
quantitation analyses must be done in biological matrices, which can often
create analytical challenges. In this study, we report the development of a
sensitive, robust, reliable, and reproducible LC-MS/MS assay for multiple
drug standards in rat plasma.

The method referenced in this application note shows
excellent linearity and reproducibility over the dynamic
range of the assay. This method demonstrates that the
TSQ Altis MS provides the sensitivity and reproducibility
required in the analysis of pharmaceutical compounds.

上一篇 高压离子色谱Inuvion快速测定自来水中的常见阴离子
下一篇 使用碎片预测与碎片离子检索（FISh）相结合的自动化方法进行高分辨率、准确质量的检测和代谢物鉴定

文献贡献者

赛默飞色谱与质谱
钻石会员 丨 第23年
查看全部资料
相关仪器 更多
相关方案
更多

相关产品

当前位置： 赛默飞色谱与质谱 方案 使用TSQ Altis三重四极杆质谱仪对血浆中候选药物混合物进行灵敏、稳健的定量分析

关注

拨打电话

留言咨询