Fast profiling of the N-glycan population in biotherapeutic antibodies by UHPLC-FLD with MS confirmation

2019/04/12   下载量： 5 次

方案摘要

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应用领域 制药/生物制药
检测样本 治疗类生物药品
检测项目
参考标准 无

This application note presents a step-by-step method for release, labeling, separation, and exoglycosidase-based structural elucidation of N-glycans from human serum IgG and commercial chimeric IgG1 mAb (infliximab) using Thermo Scientific™ Vanquish™ Horizon UHPLC-FLD and confirmation of the structures by a Thermo Scientific™ Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ mass spectrometer.

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This application note presents a step-by-step method for release, labeling, separation, and exoglycosidase-based structural elucidation of N-glycans from human serum IgG and commercial chimeric IgG1 mAb (infliximab) using Thermo Scientific™ Vanquish™ Horizon UHPLC-FLD and confirmation of the structures by a Thermo Scientific™ Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ mass spectrometer.

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赛默飞色谱与质谱
钻石会员 丨 第23年
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