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The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor,multistep continuous flow process without isolation of intermediates.
绿茶中咖啡因的超临界二氧化碳
香港环球分析:超临界二氧化碳萃取橘皮中黄酮类化合物的工艺研究
香港环球分析:顶空固相微萃取气质联用测定蒜油的挥发性成分
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