方案摘要
方案下载应用领域 | 医疗/卫生 |
检测样本 | 癌细胞/肿瘤细胞 |
检测项目 | |
参考标准 | - |
Agilent GeneSpring and Mass Profiler Professional (MPP) software was used to perform integrated multi-omics analysis of mRNA expression, miRNA expression, protein expression, and copy number aberration (CNA) associated with glioblastoma multiforme (GBM), the most frequent and lethal of the central nervous system tumors. The genomic data was obtained from The Cancer Genome Atlas (TCGA) project. The molecular subtypes defined by TCGA for GBM were based on mRNA expression. We applied GeneSpring metadata analysis framework to explore the relationship between GBM subtypes and genomic CNA. A multi-omics correlation analysis was performed between mRNAs involved in neurogenesis and their validated miRNAs highlighting the molecular events in Proneural tumors that result in suppression of p53 signaling. Furthermore, a combined analysis of mRNA expression data from TCGA with an independent, label-free GBM proteomics study revealed core subset of 54 signature genes and proteins highlighting the integrated biology analysis power of GeneSpring/MPP software. The core genomics signature clearly differentiated the known tumor subtypes in TCGA cohort. Intriguingly, while TCGA categorization of the proteomics samples were not experimentally determined, the core proteomics signature separated this cohort in 2 or 3 groups, suggesting that different TCGA subtypes may be present.
使用 Agilent 5800 ICP-OES 测定固态 电解质锂镧锆钽氧 (LLZTO) 中的 主量元素
Agilent Vaya 手持式拉曼光谱仪的 不透明容器分析能力
使用 Agilent 8890 气相色谱和 TCD/FID 系统分析氢气中的氦气、 氩气、氮气和烃类杂质
相关产品
CrossLab企业资产管理服务
Agilent GC 8890 气相色谱系统
Agilent Cary 3500 紫外可见分光光度计
Agilent Resolve 手持拉曼系统
Agilent TRS100 激光拉曼系统
Agilent 1290 Infinity II 二维液相色谱解决方案
Agilent 1290 Infinity II 液相色谱系统
Agilent 1260 Infinity II 液相色谱系统
Agilent 7900 电感耦合等离子体质谱仪
Agilent Bravo 自动液体处理平台
Agilent 7010C 三重四极杆气质联用系统
Agilent 7000E 三重四极杆气质联用系统
Agilent 5977C GC/MSD 单四极杆气质联用仪
Agilent 1290 Infinity II 高通量系统
Agilent 1290 Infinity II 方法转移系统
关注
拨打电话
留言咨询