Fragmentation analysis of drugs using TLC−PSD−MALDI−TOF

2003-07-04 16:11  下载量:156

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Thin layer chromatography (TLC) is used as a rapid and low cost screening of pharmaceutical compound purity. Often the presence of an impurity requires further characterisation by liquid chromatography mass spectrometry (LC-MS), requiring time consuming method development. It is far simpler if the MS characterisation can be performed on the same TLC plate1. SAI has collaborated with experts from Sheffield Hallam University and Pfizer Pharmaceuticals to help develop this technology.

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