微量热技术在生物制药方面的应用

2015-07-16 15:23  下载量:8

资料摘要

资料下载

The development of monoclonal antibody (Mab) based drugs has undergone considerable growth since the release of the first Mab in the mid-eighties. Intuitive biophysical tools that examine and quantify interactions and conformational dynamics are important in demonstrating and understanding local and global conformational changes. The structure of antibodies as well as other macromolecules is related to its function and efficacy therefore control over these parameters is essential. The association of antigens to antibodies or of antibodies to delivery assemblies such as liposomes or gold nanoparticles can be addressed by isothermal titration calorimetry (ITC) while the folding of antibodies can be assayed using differential scanning calorimetry (DSC). Both techniques offer the advantage of using native solutions and both instruments are offered by TA Instruments.

资料下载

文献贡献者

TA仪器
白金会员 | 第20年
查看全部资料
相关资料 更多
当前位置: TA仪器 资料 微量热技术在生物制药方面的应用

关注

拨打电话

留言咨询