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A series of unusual fused tricyclic thiochromeno[2,3-b]pyridines were successfully synthesized by tandem [3 + 3] annulation and SNAr of â-(2-chloroaroyl) thioacetanilides with activated 4-arylidene-2- phenyloxazol-5(4H)-ones or aromatic aldehydes and ethyl 2-cyanoacetate under microwave irradiation,respectively. Because of the existence of the o-chloro atom of â-(2-chloroaroyl) thioacetanilides, these reactions were very mild, convenient, and ortho-selective to form new fused tricyclic target molecules.In the domino processes, at least seven reactive distinct chemical sites were involved and up to three new covalent bonds and one tricycle with only cis configuration were generated. A synthetic study and mechanistic proposal for these transformations are presented.
微波辅助分子内酯交换法合成环收缩红霉素A衍生物
超声与微波协同作用对转谷氨酰胺酶交联的乳清蛋白结构和功能特性的影响
微波辅助合成的新型类固醇希夫碱化学传感器用于检测水介质中的Al3+。
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