ABCG2/BCRP antibody

ABCG2/BCRP antibody
Cat.#: 3765-1
Rabbit Monoclonal Antibody

Clone ID: EPR2099(2)
Swiss Prot: Q9UNQ0
Mol Weight: 72kDa
Size: 100ul

Description
ABCG2/BCRP is a membrane-associated protein that is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, ABCG2 / BCRP functions as a xenobiotic transporter, which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of ABCG2 / BCRP has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue (1).

Recommended Applications
WB

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000

Species Reactivity
Human

Species cross-reactivity is based on WB analysis

Products Data

Products Data

Western blot analysis on (A) fetal liver, (B) JAR, (C) 293T, (D) HepG2, and (E) human placenta lysates using anti-ABCG2 / BCRP RabMAb (cat. #3765-1).

Specificity
A synthetic peptide corresponding to residues in the intracellular domain in human ABCG2 / BCRP was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
ABCG2 antibody, ABC15 antibody, ABCP antibody, BCRP antibody, BCRP1 antibody, BMDP antibody, CD338 antibody, CDw338 antibody, EST157481 antibody, MGC102821 antibody, MRX antibody, MXR antibody, MXR1 antibody, ATP-binding cassette sub-family G member 2 antibody, Breast cancer resistance protein antibody, CDw338 antibody, Mitoxantrone resistance-associated protein antibody, Placenta-specific ATP-binding cassette transporter antibody

Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.