供货周期: | 一周 |
品牌: | |
规格: | 100ul |
货号: | 1768-1 |
CAS号: |
Acetyl CoA Carboxylase 1(ACC1)(ACACA)antibody
Cat.#: 1768-1
Rabbit Monoclonal Antibody
Clone ID: EP687Y
Swiss Prot: Q13085
Mol Weight: 265kDa
Size: 100ul
Description
Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).
Recommended Applications
WB, IHC
Applications and Recommended Dilution Factors
WB: 1:500 - 2000
IHC: 1:50 - 100
Species Reactivity
Human, Mouse, Rat
For Mouse, this antibody is recommended for WB only
Rat cross reactivity tested by western blot only
Products Data
Specificity
A synthetic peptide corresponding to residues in the human Acetyl-CoA carboxylase 1 was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
ACACA antibody, ACAC antibody, ACC antibody, ACC1 antibody, ACCA antibody, Biotin carboxylase antibody, ACC-alpha antibody
Description References
1. Jianqiang M, et al. PNAS 100:7515-7520, 2003.
2. Girad J, et al. The FASEB Journal 8:36-42, 1994.
3. Wakil SJ, et al. Annu Rev Biochem 52:537-539
4. Abu-Elheiga L, et al. Science 291: 2613-2616. 2001.
Product References
1. Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, et al, Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin ,FASEB J 23 (2009) 241-258
[Application: WB]
2. Ota S, Horigome K, Ishii T, et al, Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism ,Biochem Biophys Res Commun 388 (2009) 311-316
[Application: WB]
3. Yi F, Chen QZ, Jin S, et al, Mechanism of Homocysteine-Induced Rac1/ NADPH Oxidase Activation in Mesangial Cells: Role of Guanine Nucleotide Exchange Factor Vav2 ,Cell Physiol Biochem 20 (2007) 909-918
[Application: WB]
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