供货周期: | 一周 |
品牌: | |
规格: | 100ul |
货号: | 3184-1 |
CAS号: |
Androgen Receptor(AR)antibody
Cat.#: 3184-1
Rabbit Monoclonal Antibody
Clone ID: ER179(2)
Swiss Prot: P10275
Mol Weight: 110kDa
Size: 100ul
Description
Androgen receptor (AR) is a member of the steroid receptor superfamily that may require coactivators for proper or maximal transactivation. (1). The androgen receptor (AR) is essential for the growth of prostate cancer cells. It has been reported that tyrosine phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors. Data suggest that growth factors and their downstream tyrosine kinases, which are elevated during hormone-ablation therapy, can induce tyrosine phosphorylation of AR and such modification may be important for prostate tumor growth under androgen-depleted conditions (2). Cellular signaling occurs following androgen binding to the AR and translocation to the nucleus. This activated complex associates with androgen-responsive elements contained in the DNA sequence of target genes, affecting the transcriptional activity of these genes. Mutations may result in changes in the function or expression of AR protein, or of growth factors and their receptors under the influence of AR coactivators, and AR amplification could lead to activation of the receptor by reduced levels of androgens (3).
Recommended Applications
WB, IHC, ICC, IP
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:250 - 500
ICC: 1:100 - 250
IP: 1:10 - 100
Species Reactivity
Human
Species cross-reactivity is based on WB analysis
Products Data
![]() |
![]() |
![]() |
Immunofluorescent staining of LnCap cells using anti-Androgen Receptor RabMAb (cat. #3184-1).
Specificity
A synthetic peptide corresponding to residues in the N-terminus of human Androgen Receptor was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
AR antibody, AIS antibody, DHTR antibody, HUMARA antibody, HYSP1 antibody, KD antibody, NR3C4 antibody, SBMA antibody, SMAX1 antibody, TFM antibody, Androgen receptor antibody, Dihydrotestosterone receptor antibody, Nuclear receptor subfamily 3 group C member 4 antibody
Description References
1. Callewaert L, et al. Biochem Biophys Res Commun 306(1) 46-52, 2003.
2. Qiu Y, et al. Cancer Cell Vol 10:309-319, 2006.
3. Hamdy F, et al. Nature Clinical Practice Urology 2:368-399 2005.
相关产品
重组人肌球蛋白轻链2(Recombinant Human MYL2)
重组大鼠抵抗素(Rat Resistin)
3-D Life Dextran-PEG Hydrogel Kit
3-D Life Dextran-CD Hydrogel Kit(3D 细胞培养 葡聚糖马来酰亚胺-聚乙二醇仿生水凝胶试剂盒)
3-D水凝胶PEG-Link(聚乙二醇交联剂)(3D细胞培养 PEG 交联物(非降解))
3-D Life CD-Link(3D细胞培养 CD 交联物(可细胞降解))
3-D Life Maleimide-Dextran Set(3D 细胞培养葡聚糖马来酰亚胺聚合物)
3D 细胞培养RGD多肽(粘附剂)3-D Life RGD Peptide
3-D Life Scrambled RGD Peptide
Pig C-type lectin domain family 5 member A(CLEC5A)ELISA kit
Mouse C-type lectin domain family 5 member A(CLEC5A)ELISA kit
Human C-type lectin domain family 5 member A(CLEC5A)ELISA kit
无形体IgM免疫荧光试剂盒
牛甘油醛-3-磷酸脱氢酶(GAPDH)ELISA kit
鸡甘油醛-3-磷酸脱氢酶(GAPDH)ELISA kit
详细地址
关注
拨打电话
留言咨询