供货周期: | 一周 |
品牌: | |
规格: | 100ug |
货号: | T1210 |
CAS号: |
ABCB11 Antibody(C-term)
Cat.#: T1210
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: O95342
Mol Weight: 146kDa
Size: 100ug
Description
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
Recommended Applications
WB, IHC, ELISA
Applications and Recommended Dilution Factors
WB: 1:100~500
IHC: 1:50~100
ELISA: 1:1,000
Species Reactivity
Human, Mouse
Products Data
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Specificity
This ABCB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1045~1075 amino acids from the C-terminal region of human ABCB11.
Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Names
ABCB11 antibody, ABC16 antibody, BRIC2 antibody, BSEP antibody, PFIC-2 antibody, PFIC2 antibody, PGY4 antibody, SPGP antibody, Bile salt export pump antibody, ATP-binding cassette sub-family B member 11 antibody
Description References
Chen, H.L., et al., J. Pediatr. 140(1):119-124 (2002).
Saito, S., et al., J. Hum. Genet. 47(1):38-50 (2002).
Strautnieks, S.S., et al., Nat. Genet. 20(3):233-238 (1998).
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