ACAT Antibody|100ul|1864-1-上海希美化学有限公司

ACAT Antibody

参考价：¥2750

供货周期：

一周

品牌：

规格：

100ul

货号：

1864-1

CAS号：

产品详情

ACAT Antibody
Cat.#: 1864-1
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P23141
Mol Weight: 55kDa
Size: 100ul

Description
Acyl-CoA:cholesterol acyltransferase (ACAT) is an integral membrane enzyme that belongs to the type-B carboxylesterase/lipase family. ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A (1). ACAT also function as a regulator of intracellular cholesterol homeostasis at a single cell level. Two isoforms of ACAT, ACAT1 and ACAT2, are expressed in the liver and intestine. However, ACAT1 is only found in macrophages and SMCs (2). The accumulation of cholesteryl esters produced by ACAT in macrophages can lead to foam cell formation, an indication of early stage atherosclerosis. ACAT activity has been linked to Alzheimer's Disease, a condition caused by excess amount of amyloid beta-peptide (Abeta). Atherogenic lipoproteins activate ACAT activity, where active ACAT can modulate the level of Abeta (3).

Recommended Applications
WB, IHC, ICC

Applications and Recommended Dilution Factors
WB: 1:500
IHC: 1:100-1:250
ICC: 1:100-1:250

Species Reactivity
Human, Mouse, Rat

Cross reactivity determined by western blot only.

Products Data

A. Western blot analysis on fetal liver using anti-ACAT RabPAb (Cat # 1864-1), dilution 1:500.
B. Immunohistochemical analysis of paraffin-embedded human liver using anti-ACAT RabPAb (Cat# 1864-1).

Specificity
A synthetic peptide corresponding to residues in human ACAT was used as immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
CES1 antibody, ACAT antibody, CEH antibody, CES2 antibody, HMSE antibody, HMSE1 antibody, MGC117365 antibody, PCE-1 antibody, SES1 antibody, TGH antibody, Liver carboxylesterase 1 antibody, Serine esterase 1 antibody, Triacylglycerol hydrolase antibody

Description References
1. Buhman KF et al. Biochim Biophys Acta 1529(1-3):142-54, 2000

Business information

工商信息

信息已认证

企业名称: 上海希美化学有限公司
企业类型:
信用代码: 310228001203103
成立日期: 2009年05月31日
注册资本: 10
经营范围: 化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】