供货周期: | 一周 |
品牌: | |
规格: | 100ug |
货号: | T2020 |
CAS号: |
ACVR2A Antibody(N-term)
Cat.#: T2020
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P27037
Mol Weight: 58kDa
Size: 100ug
Description
ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Recommended Applications
WB, IHC, ELISA
Applications and Recommended Dilution Factors
WB: 1:100~500
IHC: 1:50~100
ELISA: 1:1,000
Species Reactivity
Human
Products Data
Specificity
This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2A.
Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Names
ACVR2A antibody, ACTRII antibody, ACVR2 antibody, Activin receptor type-2A antibody, Activin receptor type IIA antibody
Description References
Jung, B., et al., Gastroenterology 126(3):654-659 (2004).
Martins da Silva, S.J., et al., Dev. Biol. 266(2):334-345 (2004).
Olaru, A., et al., Lab. Invest. 83(12):1867-1871 (2003).
Casagrandi, D., et al., Mol. Hum. Reprod. 9(4):199-203 (2003).
Greenwald, J., et al., Mol. Cell 11(3):605-617 (2003).
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