供货周期: | 一周 |
品牌: | |
规格: | 100ul |
货号: | S2587 |
CAS号: |
alpha Actinin 4 antibody
Cat.#: S2587
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: O43707
Mol Weight: 104.87kDa
Size: 100ul
Description
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq]
Recommended Applications
WB, IHC, ICC
Applications and Recommended Dilution Factors
WB: 1:500-1:3000
IHC: 1:100-1:500,IF:1:100-1:200
ICC: 1:100-1:200
Species Reactivity
Human
Other species have not been tested
Products Data
Specificity
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 206 and 512 of alpha Actinin 4
Storage Condition and Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.
Alternative Names
ACTN4 antibody, ACTININ-4 antibody, DKFZp686K23158 antibody, FSGS antibody, FSGS1 antibody, Alpha-actinin-4 antibody, F-actin cross-linking protein antibody, Non-muscle alpha-actinin 4 antibody
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