Mouse Anti Human Protein Phosphatase-1 Regulatory Subunit-14A （PPP1R14A）

Mouse Anti Human Protein Phosphatase-1 Regulatory Subunit-14A （PPP1R14A）

参考价：¥1820
供货周期： 一周
品牌：
规格： 20µg
货号： ANT-381
CAS号：
上海希美化学有限公司
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Catalogue Number ANT-381
Synonyms Protein phosphatase 1 regulatory subunit 14A, 17 kDa PKC-potentiated inhibitory protein of PP1, CPI17, CPI-17, PPP1INL, PPP1R14A.
Type Mouse Anti Human Monoclonal.
Introduction PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. Inhibition of PPP1R14A results to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2+) concentration. Myosin phosphatase can reverse MYL (myosin light chain) phosphorylation to induce a state of relaxation. However, during agonist-induced contraction at constant Ca2+ concurrent inhibition of myosin phosphatase leads to increases in MYL phosphorylation and tension. These calcium-independent increases in myosin phosphorylation and tension are termed calcium sensitization. Human pregnancy is characterized by the increases of PKN1 expression and CPI-17 phosphorylation in the myometrium. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. PPP1R14A siRNA decreased the level of merlin phosphorylation and consequently Ras and ERK activity in human tumor cell lines. PKC/CPI-17 medi
Clone P4H10AT.
Immunogen Anti-human PPP1R14A mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PPP1R14A amino acids 1-147 purified from E. coli.
Ig Subclass Mouse IgG2a heavy chain and κ light chain.
Purification Method PPP1R14A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Protein formulation 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Storage Procedures For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.
Stability / Shelf Life 12 months at -20°C. 1 month at 4°C.
Applications PPP1R14A antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Mouse Anti Human Protein Phosphatase-1 Regulatory Subunit-14A （PPP1R14A）由上海希美化学有限公司为您提供，货号ANT-381，规格：20µg，CAS号：，如您想了解更多关于Mouse Anti Human Protein Phosphatase-1 Regulatory Subunit-14A （PPP1R14A）价格、Mouse Anti Human Protein Phosphatase-1 Regulatory Subunit-14A （PPP1R14A）结构式、批发、用途等信息，欢迎咨询。除供应Mouse Anti Human Protein Phosphatase-1 Regulatory Subunit-14A （PPP1R14A）外，还可为您提供其他等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海希美化学客户服务电话，售前、售后均可联系。
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