Mouse Anti Human Geminin （GMNN）

Mouse Anti Human Geminin （GMNN）

参考价：¥1820
供货周期： 一周
品牌：
规格： 20µg
货号： ANT-319
CAS号：
上海希美化学有限公司
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产品详情

Catalogue Number ANT-319
Synonyms GMNN, Geminin, DNA Replication Inhibitor, Gem, RP3-369A17.3.
Type Mouse Anti Human Monoclonal.
Introduction Geminin is a 25 kDa nuclear protein, which inhibits DNA replication and is degraded during the mitotic phase of the cell cycle. Geminin controls replication by binding to the licensing factor Cdt1, and is involved in neural differentiation. In addition, Geminin directly interacts with Six3 and Hox homeodomain proteins during embryogenesis and inhibits their functions. Geminin can also promote DNA replication. Geminin has 2 roles in 2 different stages of the cell cycle: Geminin is a negative regulator of DNA replication during the “S phase” of the cell cycle. Inhibition of Geminin during the “S phase” (by RNAi) results in an additional round of replication of portions of the genome. During the “M phase” of the cell cycle (mitosis) Geminin stabilizes the replication factor Cdt1 promoting DNA replication during the next cell cycle. Moreover, inhibition of Geminin during mitosis (by RNAi) causes destabilization of Cdt1 protein and impairment of DNA replication during the next cell cycle. G
Clone P2H7AT.
Immunogen Anti-human Geminin mAb is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Geminin amino acids 1-209 purified from E. coli.
Ig Subclass Mouse IgG1 heavy chain and κ light chain.
Purification Method Geminin antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Protein formulation 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Storage Procedures For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.
Stability / Shelf Life 12 months at -20°C. 1 month at 4°C.
Applications Geminin antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Mouse Anti Human Geminin （GMNN）由上海希美化学有限公司为您提供，货号ANT-319，规格：20µg，CAS号：，如您想了解更多关于Mouse Anti Human Geminin （GMNN）价格、Mouse Anti Human Geminin （GMNN）结构式、批发、用途等信息，欢迎咨询。除供应Mouse Anti Human Geminin （GMNN）外，还可为您提供其他等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海希美化学客户服务电话，售前、售后均可联系。
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