重组人精胺/精胺N1-乙酰转移酶1(Human SAT1)|5µg|ENZ-433-上海希美化学有限公司

重组人精胺/精胺N1-乙酰转移酶1(Human SAT1)

参考价：面议

供货周期：

一周

品牌：

Prospec-Tany

规格：

5µg

货号：

ENZ-433

CAS号：

ENZ-433

产品详情

SAT1 Human
Spermidine/Spermine N1-Acetyltransferase 1 Human Recombinant
Catalog No. ENZ-433

Synonyms:
Diamine acetyltransferase 1, Spermidine/spermine N(1)-acetyltransferase 1, Putrescine acetyltransferase, Polyamine N-acetyltransferase 1, SSAT-1, SSAT, SAT1, SAT, DC21, KFSD, KFSDX.

Introduction:
SAT-1 is a member the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. SAT1 catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Therefore, SAT-1’s role is essential in polyamine homoeostasis, given that acetylated products are either excreted from the cell or oxidized by acetylpolyamine oxidase. Increased SAT1 activity causes variety of other effects which include pancreatic cells death, obstruction of regenerative tissue growth, behavioral changes, keratosis follicularis spinulosa decalvans (KFSD), and hair loss.
Defects in the SAT1 gene are linked to KFSD (keratosis follicularis spinulosa decalvans), which is a rare X-linked disorder affecting the skin and the eye. The KFSD affected men show thickening of the skin of the neck, ears, and extremities, particularly the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration. Even though the majority of the affected families are compatible with an X-linked inheritance, KFSD are found to be clinically and genetically heterogeneous.

Description:
SAT1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 191 amino acids (1-171 a.a.) and having a molecular mass of 22.1kDa.
The SAT1 is purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Physical Appearance:
Sterile Filtered colorless solution.

Formulation:
The SAT1 solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.

Stability:
SAT1 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

Purity:
Greater than 95.0% as determined by SDS-PAGE.

Amino acid sequence:
MGSSHHHHHH SSGLVPRGSH MAKFVIRPAT AADCSDILRL IKELAKYEYM EEQVILTEKD LLEDGFGEHP FYHCLVAEVP KEHWTPEGHS IVGFAMYYFT YDPWIGKLLY LEDFFVMSDY RGFGIGSEIL KNLSQVAMRC RCSSMHFLVA EWNEPSINFY KRRGASDLSS EEGWRLFKID KEYLLKMATE E.

Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

重组人精胺/精胺N1-乙酰转移酶1(Human SAT1)由上海希美化学有限公司为您提供，货号ENZ-433，规格：5µg，CAS号：ENZ-433，如您想了解更多关于重组人精胺/精胺N1-乙酰转移酶1(Human SAT1)价格、重组人精胺/精胺N1-乙酰转移酶1(Human SAT1)结构式、批发、用途等信息，欢迎咨询。除供应重组人精胺/精胺N1-乙酰转移酶1(Human SAT1)外，还可为您提供重组人乙酰辅酶A乙酰转移酶2(Human ACAT2)、人胆碱乙酰转移酶(ChAT)ELISA Kit等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海希美化学客户服务电话，售前、售后均可联系。