重组人O-6-甲基鸟嘌呤-DNA甲基转移酶(Human MGMT)|5μg/20μg/1mg|ENZ-389-上海希美化学有限公司

产品详情

MGMT Human
O-6-Methylguanine-DNA Methyltransferase Human Recombinant
Catalog No. ENZ-389

Synonyms:
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferase, MGMT.

Introduction:
MGMT is an enzyme that repairs O-6-methylguanine, a mutagenic DNA base damaged by endogenous and environmental alkylating agents and takes part in the cellular defense against the biological effects of O-6-methylguanine in DNA. MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. abnormal MGMT expression correlates with the prognosis in human solid cancers. MGMT decrease of expression is correlated with methylation. The human MGMT is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damage. MGMT promoter hypermethylation plays an important role in the early steps of colorectal carcinogenesis. Abnormal promoter hypermethylation of MGMT gene is associated with oral squamous cell carcinomas.

Description:
MGMT Human Recombinant fused to 20 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 227 amino acids (1-207) and having a molecular mass of 23.8 kDa.
The MGMT is purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Physical Appearance:
Sterile Filtered clear colorless solution.

Formulation:
The MGMT solution contains 20mM Tris-HCl pH-7.5, 1mM DTT and 10% glycerol.

Stability:
MGMT Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles.

Amino Acid Sequence:
MGSSHHHHHH SSGLVPRGSH MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM QCTAWLNAYF HQPEAIEEFP VPAFHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA HEGHRLGKPG LGGSSGLAGA WLKGAGATSG SPPAGRN

Purity:
Greater than 95.0% as determined by SDS-PAGE.

Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

重组人O-6-甲基鸟嘌呤-DNA甲基转移酶(Human MGMT)由上海希美化学有限公司为您提供，货号ENZ-389，规格：5μg/20μg/1mg，CAS号：，如您想了解更多关于重组人O-6-甲基鸟嘌呤-DNA甲基转移酶(Human MGMT)价格、重组人O-6-甲基鸟嘌呤-DNA甲基转移酶(Human MGMT)结构式、批发、用途等信息，欢迎咨询。除供应重组人O-6-甲基鸟嘌呤-DNA甲基转移酶(Human MGMT)外，还可为您提供重组人烟酰胺 N-甲基转移酶(Human NNMT)、重组人组胺N-甲基转移酶(Human HNMT)、人8-羟基鸟嘌呤DNA糖苷酶(OGG1)ELISA kit等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海希美化学客户服务电话，售前、售后均可联系。

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企业名称: 上海希美化学有限公司
企业类型:
信用代码: 310228001203103
成立日期: 2009年05月31日
注册资本: 10
经营范围: 化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

供货周期：	一周
品牌：	Prospect Biosystems
规格：	5μg/20μg/1mg
货号：	ENZ-389
CAS号：