供货周期: | 一周 |
品牌: | Prospect Biosystems |
规格: | 1μg/5μg/10μg |
货号: | PKA-329 |
CAS号: |
PI3KgHis Human
Phosphoinositide 3-kinase p110g Human Recombinant
Catalog No. PKA-329
Synonyms:
Phosphoinositide 3-kinase p110g, PI3Kg.
Introduction:
PI3Kg is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3Kg-/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8a-DCs. In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3Kg.
Description:
Recombinant full length PI3Kg (126.3 kDa without Tag) carries an N-terminal His 8 affinity Tag.
Source:
Sf9 insect cells.
Physical Appearance:
Sterile Filtered clear solution.
Formulation:
0.5 mg/ml solution in 25mM HEPES, pH 8.0, 25mM NaCl, 2.5mM MgCl2, and 50% glycerol.
Stability:
PI3Kg although stable at 14ºC for 1 week, should be stored desiccated below -18ºC. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity:
Greater than 95.0% as determined by SDS-PAGE.
Biological Activity:
~ 4.5 nmol/mg/min using phosphatidylinositol as the substrate.
Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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» PI3Ka Bovine
» PI3Kb Human
» PI3Kd Human
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