Recombinant Human PGR|2μg/5μg/10μg|PRO-535-上海希美化学有限公司

产品详情

PGR Human
Progesterone Receptor Human Recombinant
Catalog No. PRO-535

Synonyms:
Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3.

Introduction:
PGR belongs to the steroid receptor superfamily. PGR is located on chromosome 11q22. The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. The progesterone receptor (PgR) is an estrogen-regulated protein. PGR mediates the physiological effects of progesterone, which plays a fundamental role in reproductive events associated with establishing and maintaining pregnancy. PGR uses 2 distinct promotors and translation start sites in the first exon to produce 2 isoforms, A & B, which differ in their molecular weight (isoform A has 165 additional amino acids at the N-terminus). The progesterone receptor has an amino and a carboxyl terminal, the regulatory domain between them, a DNA binding domain, the hinge section, and the hormone binding domain. If no hormone is bound the carboxyl terminal inhibits transcription. Binding to a hormone stimulates a structural change which eliminates the inhibitory action. Following the progesterone binding to the receptor, restructuring with dimerization begins and the complex enters the nucleus where it binds to DNA.
It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.

Description:
Progesterone Receptor Human Recombinant (a.a. 412-562) expressed in E.coli, shows a 43 kDa SDS-PAGE (including GST tag).
The PGR is purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Physical Appearance:
Sterile Filtered clear solution.

Formulation:
PGR in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.

Stability:
Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.

Applications:
• ELISA
• Inhibition Assays
• Western Blotting

Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Recombinant Human PGR由上海希美化学有限公司为您提供，货号PRO-535，规格：2μg/5μg/10μg，CAS号：，如您想了解更多关于Recombinant Human PGR价格、Recombinant Human PGR结构式、批发、用途等信息，欢迎咨询。除供应Recombinant Human PGR外，还可为您提供Recombinant Human Tubulin Folding Cofactor A(TBCA)、重组人波形蛋白(Recombinant Human Vimentin)等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海希美化学客户服务电话，售前、售后均可联系。

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工商信息

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企业名称: 上海希美化学有限公司
企业类型:
信用代码: 310228001203103
成立日期: 2009年05月31日
注册资本: 10
经营范围: 化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

供货周期：	一周
品牌：	Prospect Biosystems
规格：	2μg/5μg/10μg
货号：	PRO-535
CAS号：