A simple, cheap alternative to ‘designer convertible isonitriles expedited with microwaves through Biotage Isolera耐士科技

2015-02-13 10:04  下载量:4

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Interest in designer convertible isonitriles has increased in recent years with the growing recognition that isonitrile-based multi-component reactions (IMCRs) are highly effective in rapidly accessing, new and pharmacologically relevant diversity space. This Letter reports on the novel use of n-butylisonitrile as a cheaper and more atom-economical alternative to currently reported ‘designer convertible isonitriles’, facilitated by the advent of microwave-assisted organic synthesis (MAOS).

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