Enzymatic synthesis of tyrosol glycosides through Biotage Isolera耐士科技

2015-02-13 10:38  下载量:4

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For the purpose of synthesis of tyrosol -d-glucopyranoside (salidroside) and its -d- and -d-galactopyranoside analogues, transglycosylation of tyrosol with fungal glycosidases (from Aspergillusniger and Aspergillus oryzae) was executed. Cellobiose, lactose and melibiose served as glycosyl donor giv-ing 6.7% yield of salidroside, 10.9% of tyrosol -d-galactopyranoside, and 32.2% of -d galactopyranoside.The glycosylations proceeded on the primary hydroxyl of the tyrosol.

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