Domino bicyclization of 2,2-dihydroxyindene-1,3-dione with cyclic enaminones leading to isochromeno[4,3-b]indoles through Biotage Initiator耐士科技

2015-02-27 10:01 下载量：1

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New and practical acid-promoted domino bicyclization between 2,2-dihydroxyindene-1,3-dione and cyclic enaminones has been established for the formation of tetracyclic isochromeno[4,3-b]indoles under microwave heating. The present method simultaneously installs CeN, CeO, and CeC bonds, allowing direct assemble of functionalized isochromeno[4,3-b]indole skeleton with a wide diversity in substituents. The reaction features reliable scalability, flexibility of structural modification, and wide substrate scope as well as operational simplicity, and it can avoid time-consuming and costly syntheses, tedious work-up, and isolation of intermediate.

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上海新拓分析仪器科技有限公司

白金会员 | 第21年

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