Microwave-induced by-products in the synthesis of 2-(4-methyl-2-phenylpiperazinyl)pyridine-3-carbonitrile by Biotage Initiator耐士科技

2015-02-27 10:32 下载量：1

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The Letter describes the investigation of an industrial reaction of N-methylphenylpiperazine and chloro nicotinonitrile, under microwave heating. Besides the formation of the expected 2-(4-methyl-2-phe nylpiperazinyl)pyridine-3-carbonitrile (4), extension of the scale leads to unexpected by-products. A specific pathway due to the formation of a reactive ‘ionic alkylating intermediate’ formed in situ under microwave conditions is proposed to explain the results observed.

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上海鑫欣生物科技有限公司

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