资料摘要
资料下载Neu5Ac2en1Me per-OAc, the fully protected glycal of sialic acid, is a key intermediate in the discovery of therapeutics and diagnostics, including anti-influenza drugs and proteolysis resistant peptidomimetic foldamers. The synthesis of this sialic acid derivative, however, still relies on standard sugar chemistry that utilizes multi-step methodologies. Herein we report a facile and highly efficient microwave-assisted preparation of Neu5Ac1Me using silica sulfuric acid (SSA) as solid-supported acid catalyst that is one- to two-orders of magnitude faster than standard procedures. We also describe the microwave-assisted and SSA-catalyzed one-pot, rapid, solvent free reaction that combines both peracetylation and b-elimination reactions in one step to generate the glycal from Neu5Ac1Me. We coined the term One-pot SSA-catalyzed Technology for b-Elimination Protocol (OneSTEP) to describe this least laborious, most efficient, and practical preparation to date of Neu5Ac2en1Me per-OAc in terms of yield, time, reagent cost, and waste generation.
Thiadiazolidine 1-oxide systems for phosphine-free palladium-mediated catalysis by Biotage Initiator耐士科技
简介:We herein report several highly active catalyst systems with thiadiazolidine 1-oxides as ligands for palladium in the MizorokieHeck reaction. Excellent yields of stilbenes derived from aryl iodides and bromides have been achieved using as little as 0.00002 mol % catalyst. The ligand/palladiumsystem can be stored as a stock solution open to air at room temperature with no observable loss of activity for a period of several months.
Biotage Flash Isolera 快速制备液相色谱注意事项
简介:耐士科技作为Biotage中国区总代理,以优质的服务为您提供Biotage全系产品以及相关的技术服务。1、开机前确认自动收集机械手臂下无障碍物,试管高度低于机械手臂收集针 2、运行前确认所用流动相充足,废液瓶剩余空间充足
Biotage Isolera中低压制备快速使用手册
简介:操作步骤: 1.开机,按屏幕左下方黑色电源键 2.进入开机界面后,点击Chemistry进入操作界面 3.在”Method”页面中设定好相关参数
微波合成仪Initiatior快速使用手册
简介:耐士科技作为Biotage中国区总代理,以优质的服务为您提供Biotage全系产品以及相关的技术服务。 操作步骤: 1.开机,按屏幕左下方黑色电源键 2.进入开机界面后,点击 Organic Synthesis 进入编辑界面
氨基柱的使用与保养
简介:GRACE氨基柱可同时用于正相条件和反相条件,但是在一般情况下,正相溶剂与反相溶剂是不互溶的,在更换正反相时请先用异丙醇过渡,因为异丙醇粘度较大,因此流速建议调至0.5ml/min。 了解更多或订购产品,请致电耐士科技全国服务热线:400-188-0725
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