供货周期: | 一周 |
品牌: | |
规格: | 1μg/2.5μg/5μg |
货号: | PKA-333 |
CAS号: |
PI3Kb Human
Phosphoinositide 3-kinase beta p110β/p85α Human Recombinant
Catalog No. PKA-333
Synonyms:
Phosphoinositide 3-kinase beta p110β/p85α, PI3K β, PI3Kb.
Introduction:
The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of
PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin receptor substrate (IRS) proteins (e.g. IRS-1 and IRS-2).
It was also shown that PI3Kb is involved in apoptosis in human colon carcinoma cells. Injection of neutralizing antibodies specific to p110b in WiDr,
HCT116 and CO 115 adenocarcinoma cells inhibited de novo DNA synthesis.
PI3Kb is the major PI3K isoform required for apoptotic cell and Fc-g receptor mediated phagocytosis shown for primary mouse macrophages and the Jurkat human leukemia T cell line.
It was shown by several research groups that the catalytic subunit of PI3Kb can be activated by Gbg subunits of G-protein coupled receptors.
Description:
Phosphoinositide 3-kinase beta Human Recombinant is a glycosilated protein having a molecular weight as follows: p85α chain 83.5 kDa, p110β chain 124.3 kDa.
Source:
Sf9 insect cells.
Physical Appearance:
Sterile filtered liquid formualtion.
Formulation:
0.5 mg/ml solution in 10mM Hepes, pH 7.5, 100mM NaCl, 2.5mM MgCl2, and 50% glycerol.
Stability:
PI3Kb although stable at 4°C for 1 week, should be stored desiccated below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity:
Greater than 90.0% as determined by SDS Page.
Biological Activity:
~ 3 nmol/mg/min using phosphatidylinositol as the substrate.
Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Related Products
» PI3Ka Bovine
» PI3Kd Human
» PI3KgHis Human
» PI3KγD946GST Human
相关产品
重组人肌球蛋白轻链2(Recombinant Human MYL2)
重组大鼠抵抗素(Rat Resistin)
大鼠酸性磷酸酶(ACP)ELISA Kit
大鼠胆囊收缩素/缩胆囊素八肽(CCK-8)ELISA Kit
人瘦素(LEP)ELISA Kit
重组人半乳糖凝集素16/LGALS16 Human
重组人半乳糖凝集素8/Human LGALS8 His
重组人半乳糖凝集素3/Human LGALS3 His
重组人卵泡抑素/Human FST His
重组人β防御素118/DEFB118 Human
重组人心肌营养素1/CTF1 Human
特级新生牛血清(无支原体)
超级新生牛血清(无支原体)
优级胎牛血清(无支原体)
特级新生牛血清(无噬菌体低内毒素)
详细地址
关注
拨打电话
留言咨询