重组人卵泡抑素/Human FST

报价:¥2000
供货周期: 7天
品牌: Prospec-Tany
型号: 20ug
货号: CYT-232
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产品详情

重组人卵泡抑素/Human FST

Follistatin Human Recombinant


产品详情:

CATALOGUE NUMBER

CYT-232

SYNONYMS

FST, FS, Activin-binding protein.

INTRODUCTION

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).

DESCRIPTION

Follistatin Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids and having a total molecular mass of 31.5kDa.
The FST is purified by proprietary chromatographic techniques.

SOURCE

Escherichia Coli.

PHYSICAL APPEARANCE

Sterile Filtered White lyophilized (freeze-dried) powder.

FORMULATION

Lyophilized from a concentrated (1mg/ml) solution containing no additives.

SOLUBILITY

It is recommended to reconstitute the lyophilized Follistatin in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.

STABILITY

Lyophilized Follistatin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FST should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

PURITY

Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

AMINO ACID SEQUENCE

The sequence of the first five N-terminal amino acids was determined and was found to be Gly-Asn-Cys-Trp-Leu.

BIOLOGICAL ACTIVITY

The activity is determined by the ability to neutralize Activin A inhibitory effect of mouse MPC-11 cells. The expected ED50 is 100-400ng/ml, corresponding to a Specific Activity of 2,500-10,000units/mg in the presence of 7.5ng/ml Activin A.

USAGE

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.


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重组人卵泡抑素/Human FST由上海高创化学科技有限公司为您提供,货号CYT-232,规格:20ug,CAS号:,如您想了解更多关于重组人卵泡抑素/Human FST价格、重组人卵泡抑素/Human FST结构式、批发、用途等信息,欢迎咨询。除供应重组人卵泡抑素/Human FST外,还可为您提供大鼠卵泡抑素(FS)ELISA Kit、重组小鼠卵泡抑素/Mouse FST等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,上海高创客户服务电话,售前、售后均可联系。
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