Aprepitant(MK-0869)|2mg|K1294-上海高创化学科技有限公司

Aprepitant(MK-0869)

参考价：¥1298

供货周期：

一周

品牌：

规格：

2mg

货号：

K1294

CAS号：

SKU:K1294		M. Wt:534.43
Formula:C23H21F7N4O3		Solubility:N/A
Purity:>99%		Storage:2 years -20°C Powder
CAS No.:170729-80-3		Synonyms:MK-869, L-754030, Emend
Chemical NameN/A

Description	The substance P receptor antagonist MK-0869 shows antidepressant and anxiolytic activity in depressed outpatients which was comparable to a standard SSRI.
Targets
IC50	N/A
In vitro	MK-869 is the substance P inhibitor. MK-869 showed antidepressant and anxiolytic activity.
In vivo	The substance P receptor antagonist MK-0869 shows antidepressant and anxiolytic activity in depressed outpatients which was comparable to a standard SSRI.In a 4 h observation period, MK-0869 and L-758,298 (3 mg/kg i.v. or p.o.) inhibited the emetic response to cisplatin (10 mg/kg i.v.).In a model of acute and delayed emesis, Pretreatment with MK-0869 (4-16 mg/kg p.o.) dose-dependently inhibited the emetic response to cisplatin. Once daily oral administration of MK-869 was effective in reducing delayed emesis and nausea after high-dose cisplatin.
Clinical Trials	N/A
Features	N/A

Description

The substance P receptor antagonist MK-0869 shows antidepressant and anxiolytic activity in depressed outpatients which was comparable to a standard SSRI.

Targets

IC50

N/A

In vitro

MK-869 is the substance P inhibitor. MK-869 showed antidepressant and anxiolytic activity.

In vivo

The substance P receptor antagonist MK-0869 shows antidepressant and anxiolytic activity in depressed outpatients which was comparable to a standard SSRI.In a 4 h observation period, MK-0869 and L-758,298 (3 mg/kg i.v. or p.o.) inhibited the emetic response to cisplatin (10 mg/kg i.v.).In a model of acute and delayed emesis, Pretreatment with MK-0869 (4-16 mg/kg p.o.) dose-dependently inhibited the emetic response to cisplatin. Once daily oral administration of MK-869 was effective in reducing delayed emesis and nausea after high-dose cisplatin.

Clinical Trials

N/A

Features

N/A