| SKU:K1301 | M. Wt:424.47 | ||
| Formula:C22H20N2O5S | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:173529-46-9 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1301 |
| CAS号： | 173529-46-9 |
| SKU:K1301 | M. Wt:424.47 | ||
| Formula:C22H20N2O5S | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:173529-46-9 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| Description | HMN-214 | |||||
|---|---|---|---|---|---|---|
| Targets | PLK1 | |||||
| IC50 | 118 nM | |||||
| In vitro | HMN-214 (IVX-214) is a potent inhibitor of Polo-like kinase (Plk)1 with IC50 of 118 nM. The in vitro data may be similar to that of HMN-176, which is active metabolite of HMN-214. | |||||
| In vivo | HMN-214 has a potent antitumor activity in mouse xenograft models. When administered p.o., HMN-214 suppressed the expression of MDR1 mRNA in a mouse xenograft model implanted with KB-A.1, an Adriamycin-resistant cell line. HMN-214 is an oral prodrug because of the poor oral absorption of HMN-176 itself. The antitumor activity of HMN-214 against human tumor xenografts was equal or superior to that of clinically available agents, including cis-platinum, adriamycin, vincristine, and UFT without severe toxicity such as neurotoxicity. The maximum tolerated dose of HMN-214 when administered is 8 mg/m2/d. | |||||
| Clinical Trials | N/A | |||||
| Features | N/A | |||||
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