| SKU:K1306 | M. Wt:563.47 | ||
| Formula:C27H28F2N6O.2HCl | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:1092499-93-8 (free base) | Synonyms:N/A | ||
| Chemical NameN/A | |||
| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1306 |
| CAS号： | 1092499-93-8 |
| SKU:K1306 | M. Wt:563.47 | ||
| Formula:C27H28F2N6O.2HCl | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:1092499-93-8 (free base) | Synonyms:N/A | ||
| Chemical NameN/A | |||
| Description | NVP-BSK805 | |||||
|---|---|---|---|---|---|---|
| Targets | JAK2 | |||||
| IC50 | 0.5 nM | |||||
| In vitro | NVP-BSK805 can potently suppress JAK2 with IC50 of 0.5 nM, and displays more than 20-fold selectivity towards JAK1, JAK3, and TYK2. NVP-BSK805 shows inhibition to causes JAK2V617F and JAK2 wild-type with IC50 of 0.5 nM. For cell lines, NVP-BSK805 inhibt JAK2V617F cells (Ba/F3) growth and induce cell apoptosis. NVP-BSK805 also can potently inhibit STAT5. By inducing activation of caspase cascades, NVP-BSK805 triggered cell death. | |||||
| In vivo | In a Ba/F3 JAK2V617F cell driven mouse model, oral administration of NVP-BSK805(150 mg/kg) shows suppression to STAT5 phosphorylation, splenomegaly, and leukemic cell spreading. | |||||
| Clinical Trials | N/A | |||||
| Features | N/A | |||||
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